Supplemental study on 2’, 3’-Cyclic Nucleotide 3’-Phosphodiesterase (CNPase) activity in developing rat spinal cord lesions induced by hexachlorophene and cuprizone
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چکیده
منابع مشابه
Hexachlorophene and cuprizone induce the spongy change of the developing rat brain by different mechanisms: the role of 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase).
The goal of this research was to identify mechanisms responsible for the spongy change induced in rats after repeated hexachlorophene (HCP) or cuprizone (CPZ) dosing. Rats were dosed with 35 mg/kg HCP for 5 days followed by drug withdrawal for 7 days suffered spongy changes to the white matter of the cerebrum, cerebellum, medulla oblongata, and spinal cord that were accompanied by degeneration ...
متن کاملActivity of 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in spinal cord with spongy change induced by a single oral dose of aniline in rats.
A spongy change in the spinal cord white matter was observed in four-week-old rats treated with aniline. Although this change was found to be a result of the myelin sheath splitting at the ultrastructural level, the mechanism is unknown. This study was conducted to identify the mechanism of the spongy change in aniline-treated rats. The spongy change in the spinal cord white matter was first de...
متن کامل3'-cyclic nucleotide 3'-phosphodiesterase
1. A spectrophotometric assay of 2':3'-cyclic nucleotide 3'-phosphodiesterase (EC 3.1.4.37) based on the use of an acid-base indicator and a buffer having identical PKa values is described. The assay is sinmple and rapid; it was particularly convenient for monitoring the enzyme activity at vat :ous stages of purification. 2. Several proteinases were examined for their ability to solubilize 2':3...
متن کاملRole of 2',3'-cyclic nucleotide 3'-phosphodiesterase in the renal 2',3'-cAMP-adenosine pathway.
Energy depletion increases the renal production of 2',3'-cAMP (a positional isomer of 3',5'-cAMP that opens mitochondrial permeability transition pores) and 2',3'-cAMP is converted to 2'-AMP and 3'-AMP, which in turn are metabolized to adenosine. Because the enzymes involved in this "2',3'-cAMP-adenosine pathway" are unknown, we examined whether 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP...
متن کاملCa -dependent permeability transition regulation in rat brain mitochondria by 2 ,3 -cyclic nucleotides and 2 ,3 -cyclic nucleotide 3 -phosphodiesterase
Azarashvili T, Krestinina O, Galvita A, Grachev D, Baburina Y, Stricker R, Evtodienko Y, Reiser G. Ca -dependent permeability transition regulation in rat brain mitochondria by 2 ,3 -cyclic nucleotides and 2 ,3 -cyclic nucleotide 3 -phosphodiesterase. Am J Physiol Cell Physiol 296: C1428–C1439, 2009. First published April 8, 2009; doi:10.1152/ajpcell.00006.2009.—Recent evidence indicates that 2...
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ژورنال
عنوان ژورنال: Journal of Veterinary Medical Science
سال: 2019
ISSN: 0916-7250,1347-7439
DOI: 10.1292/jvms.19-0096